Long-term neurodevelopmental outcome after intrauterine transfusion for hemolytic disease of the fetus/newborn: the LOTUS study
American Journal of Obstetrics and Gynecology 2012;206(2):141.e1-141.e8
Lindenburg IT, Smits-Wintjens VE, van Klink JM, Verduin E, van Kamp IL, Walther FJ, Schonewille H, Doxiadis II, Kanhai HH, van Lith JM, van Zwet EW, Oepkes D, Brand A, Lopriore E, LOTUS Study Group
Summary
The LOTUS study followed children who received one or more blood transfusions before birth for haemolytic disease. 291 children were assessed at a median age of just over eight years with standardised tests, including the Bayley and Wechsler scales. The outcome was neurodevelopmental impairment: cerebral palsy, severe developmental delay, deafness or blindness. The incidence proved low. Severe hydrops before treatment was the strongest predictor. Timely detection, referral and treatment may prevent hydrops.
Summary based on the published abstract.
- Type
- Cohort study
- Role
- First author
- Subjects
- intrauterine blood transfusion, long-term neurodevelopmental outcome, haemolytic disease of the fetus and newborn
- PMID
- 22030316